BDNF levels are not related with levodopa‐induced dyskinesias in MPTP monkeys
Identifieur interne : 001C61 ( Main/Exploration ); précédent : 001C60; suivant : 001C62BDNF levels are not related with levodopa‐induced dyskinesias in MPTP monkeys
Auteurs : Pershia Samadi [Canada] ; Marc Morissette [Canada] ; Daniel Lévesque [Canada] ; Thérèse Di Paolo [Canada]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-01-15.
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Abstract
Levodopa‐induced dyskinesias (LIDs) are frequent in parkinsonian patients and may result from an aberrant plasticity. Brain‐derived neurotrophic factor (BDNF) represents a likely candidate to subserve neuroadaptive processes encountered in LIDs. We compared striatal BDNF levels measured by ELISA in levodopa‐treated 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) monkeys having developed LIDs compared with animals where LIDs were prevented by the addition of CI‐1041 (NR1A/2B NMDA receptor antagonist) or low doses of cabergoline (dopamine D2 receptor agonist). We observed reduced striatal BDNF concentrations in levodopa‐treated MPTP monkeys with or without LIDs, suggesting that levodopa treatment is associated with reduced striatal BDNF levels and is independent of dyskinesias. © 2009 Movement Disorder Society
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DOI: 10.1002/mds.22885
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-01-15">2010-01-15</date><biblScope unit="volume">25</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="116">116</biblScope><biblScope unit="page" to="121">121</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">F760C4D45322B30B0357133D901CD4F22091209A</idno><idno type="DOI">10.1002/mds.22885</idno><idno type="ArticleID">MDS22885</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>BDNF</term><term>NMDA antagonist</term><term>Parkinson</term><term>basal ganglia</term><term>cabergoline</term><term>dyskinesia</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Levodopa‐induced dyskinesias (LIDs) are frequent in parkinsonian patients and may result from an aberrant plasticity. 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We observed reduced striatal BDNF concentrations in levodopa‐treated MPTP monkeys with or without LIDs, suggesting that levodopa treatment is associated with reduced striatal BDNF levels and is independent of dyskinesias. © 2009 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Samadi, Pershia" sort="Samadi, Pershia" uniqKey="Samadi P" first="Pershia" last="Samadi">Pershia Samadi</name></noRegion><name sortKey="Di Paolo, Therese" sort="Di Paolo, Therese" uniqKey="Di Paolo T" first="Thérèse" last="Di Paolo">Thérèse Di Paolo</name><name sortKey="Di Paolo, Therese" sort="Di Paolo, Therese" uniqKey="Di Paolo T" first="Thérèse" last="Di Paolo">Thérèse Di Paolo</name><name sortKey="Di Paolo, Therese" sort="Di Paolo, Therese" uniqKey="Di Paolo T" first="Thérèse" last="Di Paolo">Thérèse Di Paolo</name><name sortKey="Levesque, Daniel" sort="Levesque, Daniel" uniqKey="Levesque D" first="Daniel" last="Lévesque">Daniel Lévesque</name><name sortKey="Morissette, Marc" sort="Morissette, Marc" uniqKey="Morissette M" first="Marc" last="Morissette">Marc Morissette</name><name sortKey="Samadi, Pershia" sort="Samadi, Pershia" uniqKey="Samadi P" first="Pershia" last="Samadi">Pershia Samadi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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